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[慢性青少年关节炎]

[Chronic juvenile arthritis].

作者信息

Koné-Paut I

机构信息

Unité de recherche en épidémiologie et immuno-oncologie pédiatriques Faculté de médecine Hôpital Nord, Marseille.

出版信息

Rev Prat. 1994 Dec 1;44(19):2561-7.

PMID:7855522
Abstract

Juvenile chronic arthritis encompasses a heterogeneous spectrum of diseases that all include at least one persistent inflammatory arthritis. Its definition is based upon clinical criteria after exclusion of a long list of differential diagnoses. Three main types of onset are generally considered according to the clinical features during the first 3 months of evolution: systemic (20%), oligoarticular (50%), polyarticular (30%). Systemic forms present with acute general symptoms and a wide variety of articular features, from polyarthritis to isolated arthralgias. Oligoarticular forms involve 4 or fewer joints and are often complicated with iridocyclitis especially in case of positive antinuclear antibodies in the serum. Polyarticular forms involve at least 5 joints and include the presence of rheumatoid factor in the serum in 10% of cases. The clinical course of juvenile chronic arthritis is unpredictable and the reliability of the current classification is limited by taking into account only the first 3 months of evolution.

摘要

青少年慢性关节炎涵盖了一系列异质性疾病,所有这些疾病都至少包括一种持续性炎性关节炎。其定义基于排除一长串鉴别诊断后的临床标准。根据疾病演变最初3个月的临床特征,通常认为有三种主要起病类型:全身型(20%)、少关节型(50%)、多关节型(30%)。全身型表现为急性全身症状以及从多关节炎到孤立关节痛等各种各样的关节特征。少关节型累及4个或更少关节,常并发虹膜睫状体炎,尤其是血清抗核抗体呈阳性的情况下。多关节型累及至少5个关节,10%的病例血清中存在类风湿因子。青少年慢性关节炎的临床病程不可预测,目前的分类可靠性有限,因为仅考虑了疾病演变的最初3个月。

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