Fang Y Y
Guandong Institute of Parasitic Diseases, Guangzhou, People's Republic of China.
Southeast Asian J Trop Med Public Health. 1994 Jun;25(2):291-5.
Extensive survey of the distribution of the liver fluke Clonorchis sinensis in Guandong Province, China, has revealed high frequencies in human populations in some areas and absence in others. The distribution relates in part to the demography of first and second intermediate hosts and animal reservoir hosts, but it relates more clearly to the differing food habits of various populations in particular geographic areas. Thus clonorchiasis is concentrated in the Zhu Jiang (Pearl River) delta and along the Han Jiang (Han River) but is absent in the Leizhou Peninsula and in the western region of the province. Males tend to have higher infection rates than females. Age distribution is not uniform: in some communities infection rates increase with age where adults eat raw or undercooked fish, while in other infections reaches its peak in early teenage children and declines thereafter where children eat small raw fish but the habit does not persist into adult life. While there is some evidence that high C. sinensis rates correlate with high liver cancer rates and vice versa, this issue requires in depth investigation at community level to differentiate hepatocellular carcinoma and early cholangiocarcinoma, since it is possible that C. sinensis infection promotes higher risk of the latter form of liver cancer.
对中国广东省华支睾吸虫（肝吸虫）分布情况的广泛调查显示，某些地区人群中的感染率很高，而其他地区则没有感染情况。这种分布部分与第一中间宿主、第二中间宿主以及动物储存宿主的种群统计学特征有关，但更明显地与特定地理区域内不同人群的饮食习惯差异有关。因此，华支睾吸虫病集中在珠江三角洲和韩江沿岸，但在雷州半岛和该省西部地区没有此病。男性的感染率往往高于女性。年龄分布并不均匀：在一些社区，成年人食用生鱼或未煮熟的鱼，感染率随年龄增长而上升；而在其他社区，儿童食用小的生鱼，但这种习惯不会持续到成年，感染率在青少年早期达到峰值，之后下降。虽然有一些证据表明华支睾吸虫高感染率与肝癌高发病率相关，反之亦然，但这个问题需要在社区层面进行深入调查，以区分肝细胞癌和早期胆管癌，因为华支睾吸虫感染可能会增加后一种肝癌的发病风险。
