亚急性给予甲苯对大鼠脑啡肽能神经调节系统的影响及神经节苷脂治疗的保护作用。

Effect of subacute toluene administration on the enkephalinergic neuromodulatory system in rats and protective action of ganglioside treatments.

作者信息

De Gandarias J M, Echevarria E, Serrano R, Irazusta J, Casis L

机构信息

Department of Physiology Medical School, University of the Basque Country, Bilbao, Spain.

出版信息

Toxicol Ind Health. 1994 May-Jun;10(3):155-61. doi: 10.1177/074823379401000305.

DOI:10.1177/074823379401000305

PMID:7855865

Abstract

Gangliosides perform protective functions in the central nervous system. This paper describes a study of the effect of ganglioside administration on toluene neurotoxicity. Rat brain met-enkephalin immunostaining in the central amygdaloid nuclei showed changes in rats treated simultaneously with gangliosides and toluene with respect to rats treated with toluene alone. It is suggested that gangliosides prevent toluene neurotoxicity at this level, leading to hypothetical neurobehavioral changes.

摘要

神经节苷脂在中枢神经系统中发挥保护作用。本文描述了一项关于给予神经节苷脂对甲苯神经毒性影响的研究。在杏仁中央核中，大鼠脑甲硫氨酸脑啡肽免疫染色显示，同时给予神经节苷脂和甲苯的大鼠与仅给予甲苯的大鼠相比有变化。提示神经节苷脂在此水平预防甲苯神经毒性，导致假设的神经行为改变。