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The multifunctional TFIIH complex and transcriptional control.

作者信息

Drapkin R, Reinberg D

机构信息

Howard Hughes Medical Institute, Department of Biochemistry, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway 08854-5635.

出版信息

Trends Biochem Sci. 1994 Nov;19(11):504-8. doi: 10.1016/0968-0004(94)90139-2.

DOI:10.1016/0968-0004(94)90139-2
PMID:7855896
Abstract

RNA polymerase II (Pol II) requires seven general transcription factors (GTFs) and ATP for transcription initiation. Transcription factor IIH (TFIIH) has emerged as the sole GTF with enzymatic activity. In addition to its essential role in transcription initiation, recent studies have demonstrated a direct involvement of TFIIH in DNA excision repair processes. The enzymatic properties and functional duality of TFIIH make it a prime target for regulation by viral and cellular factors.

摘要

相似文献

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The multifunctional TFIIH complex and transcriptional control.
Trends Biochem Sci. 1994 Nov;19(11):504-8. doi: 10.1016/0968-0004(94)90139-2.
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TFIIH action in transcription initiation and promoter escape requires distinct regions of downstream promoter DNA.转录起始和启动子逃逸过程中TFIIH的作用需要下游启动子DNA的不同区域。
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Multiple functions of general transcription factors TFIIE and TFIIH in transcription: possible points of regulation by trans-acting factors.通用转录因子TFIIE和TFIIH在转录中的多种功能：反式作用因子可能的调控点。
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