Wang K K, Yuen P W
Department of Neuroscience Pharmacology, Parke-Davis Pharmaceutical Research, Warner-Lambert Company, Ann Arbor, MI 48105.
Trends Pharmacol Sci. 1994 Nov;15(11):412-9. doi: 10.1016/0165-6147(94)90090-6.
Increasing evidence now suggests that excessive activation of the Ca(2+)-dependent protease calpain could play a key or contributory role in the pathology of a variety of disorders, including cerebral ischaemia, cataract, myocardial ischaemia, muscular dystrophy and platelet aggregation. In this review, Kevin Wang and Po-Wai Yuen discuss the evidence linking these disorders to calpain overactivation. At present, it is difficult to confirm the exact role of calpain in these disorders because of the lack of potent, selective and cell-permeable calpain inhibitors. However, given the multiple therapeutic indications for calpain, it appears that achievement of selective calpain inhibition is an important pharmacological goal.
