Wegner H E, Knispel H H, Klän R, Meier T, Miller K
Department of Urology, Universitätsklinikum Steglitz, Freie Universität Berlin, Germany.
Urol Int. 1994;53(4):214-6. doi: 10.1159/000282674.
Recent experimental work has demonstrated that nitric oxide (NO) is the neurotransmitter responsible for cavernous smooth muscle relaxation. Different studies on the performance of the direct NO donor linsidomine chlorhydrate (SIN-1) in patients with erectile dysfunction have had conflicting results. We performed a single-blind cross-over trial in 20 patients with erectile dysfunction of mixed etiology comparing prostaglandin E1 (PGE1) to SIN-1 at two different dosages (1 and 2 mg, respectively) in order to determine the effectiveness of SIN-1. PGE1 always achieved the best response, SIN-1 performed statistically significantly poorer irrespective of the dosage used. There were only a few side effects with no significant difference. SIN-1 is not a useful alternative to PGE1 in the treatment of erectile dysfunction.
近期的实验研究表明，一氧化氮（NO）是负责海绵体平滑肌舒张的神经递质。关于直接NO供体盐酸林西多明（SIN-1）在勃起功能障碍患者中的疗效的不同研究结果相互矛盾。我们对20例病因混合的勃起功能障碍患者进行了一项单盲交叉试验，比较了前列腺素E1（PGE1）与两种不同剂量（分别为1毫克和2毫克）的SIN-1，以确定SIN-1的有效性。PGE1始终取得最佳反应，无论使用何种剂量，SIN-1的表现均在统计学上显著较差。只有少数副作用，且无显著差异。在治疗勃起功能障碍方面，SIN-1不是PGE1的有效替代药物。
