Valyshev A V, Zykova L S, Konnova M E
Zh Mikrobiol Epidemiol Immunobiol. 1994 Aug-Sep;Suppl 1:71-4.
A screening method for the evaluation of the state of intestinal microbiocenosis by monitoring the persistence sign of bacteria, their anti-interferon activity, was proposed. The examination of patients with dysbiosis of the intestine has shown that their intestinal microflora was found capable of inactivating the preparation of human leukocytic interferon at a definite concentration 8.7 times more often than the intestinal microflora of healthy persons. The number of interferon-active colonies correlated with the severity of changes in intestinal microbiocenosis and the degree of clinical manifestations of the disease.
提出了一种通过监测细菌的持续存在迹象及其抗干扰素活性来评估肠道微生物群落状态的筛查方法。对肠道菌群失调患者的检查表明,他们的肠道微生物群能够使一定浓度的人白细胞干扰素制剂失活,其频率比健康人的肠道微生物群高8.7倍。干扰素活性菌落的数量与肠道微生物群落变化的严重程度以及疾病临床表现的程度相关。