Trémeau G, Bozio A, Chapuis F, Sassolas F, Champsaur G, Ninet J, Di Filippo S, André M, Normand J
Service de cardiologie C, Hôpital cardiovasculaire et pneumologique, BP Lyon-Monchat.
Arch Mal Coeur Vaiss. 1994 May;87(5):615-22.
The authors analysed the anatomical and clinical prognostic factors of single or common ventricle. This retrospective study was based on a series of 185 patients hospitalised between 1/2/70 and 31/12/91 in the paediatric cardiological unit of the Cardiological Hospital of Lyon with this condition. A number of anatomical and clinical parameters were identified in this population. For each parameter, a given patient could only relate to single modality and a survival graph determined by Kaplan-Meier analysis was established for each modality. For each variable, the survival curve of the most frequently encountered modality served as a reference and the other modalities were compared with it using a logrank test. The different modalities potentially related to patient survival were then entered into a multivariable model using logistic regression. The results of this study of multivariable analysis using the Odds-Ratio (OR) independently suggest that four variables may influence negatively survival of patients with a single ventricle: pH < or = 7.3 on admission (OR = 3.55), a non-left ventricular morphology of the main ventricular chamber (OR = 3.11), the presence of an obstacle on the aortic outflow (OR = 5.58) and a total anomalous pulmonary venous drainage (OR = 26.88).
作者分析了单心室或共同心室的解剖学和临床预后因素。这项回顾性研究基于1970年2月1日至1991年12月31日期间在里昂心脏病医院儿科心脏病科住院的185例患有这种疾病的患者。在该人群中确定了一些解剖学和临床参数。对于每个参数，给定患者只能属于单一模式，并为每种模式建立了通过Kaplan-Meier分析确定的生存图。对于每个变量，最常出现的模式的生存曲线用作参考，并使用对数秩检验将其他模式与之进行比较。然后，使用逻辑回归将可能与患者生存相关的不同模式纳入多变量模型。使用比值比（OR）进行的这项多变量分析研究结果独立表明，四个变量可能对单心室患者的生存产生负面影响：入院时pH≤7.3（OR = 3.55）、主心室腔非左心室形态（OR = 3.11）、主动脉流出道存在梗阻（OR = 5.58）和完全性肺静脉异位引流（OR = 26.88）。
