Munoz A, Guichard J P, Reginault P
Atherosclerosis. 1994 Oct;110 Suppl:S45-8. doi: 10.1016/0021-9150(94)05375-s.
Rationale and development of a new fenofibrate formulation is described. A lower dispersion of particles size and thereby a better absorption rate leads to a decrease of the daily dose and provides a better control of the amount absorbed. Improved reproducibility of the pharmacological and therapeutic effect is expected.
描述了一种新的非诺贝特制剂的基本原理和研发情况。颗粒尺寸的更低分散度以及由此带来的更好吸收速率导致每日剂量降低,并能更好地控制吸收量。预计可提高药理和治疗效果的重现性。