Hernández González M, Oropeza M V, Guevara M A, Cervantes M, Moralí G
Unidad de Investigación Médica en Farmacología, Hospital de Especialidades, IMSS, México, D.F.
Arch Med Res. 1994 Winter;25(4):419-25.
The effects of the intrathecal perispinal administration of adrenergic agonists on the characteristics of frequency, duration, and vigor of pelvic thrusting displayed by male rats during copulation was assessed by an accelerometric technique. A different dose of one drug (noradrenaline, clonidine or isoproterenol) and saline as control was administered at the lumbosacral level of the spinal cord to sexually active male rats in tests of sexual behavior performed at weekly intervals. The intrathecal administration of noradrenaline (alpha-adrenoceptor agonist) increased the frequency of pelvic thrusting in mount and intromission responses, whereas both the alpha 2-adrenoceptor agonist clonidine (25 micrograms) and the beta-adrenoceptor agonist isoproterenol (40 micrograms) reduced the frequency of pelvic thrusting in these responses as compared to values obtained under the intrathecal administration of saline. On the other hand, the duration of the thrusting trains and the potency or vigor of pelvic thrusting in mounts and intromissions did not differ from values obtained under saline treatment. These findings indicate a possible participation of noradrenaline in the modulation of the spinal mechanisms involved in the generation of rhythmic pelvic thrusting performed by the male rat during copulation.
采用加速度测量技术评估了鞘内脊髓周围注射肾上腺素能激动剂对雄性大鼠交配时骨盆推撞频率、持续时间和力度特征的影响。在每周进行的性行为测试中，对性活跃的雄性大鼠在脊髓腰骶水平给予不同剂量的一种药物（去甲肾上腺素、可乐定或异丙肾上腺素）以及作为对照的生理盐水。鞘内注射去甲肾上腺素（α-肾上腺素能受体激动剂）增加了爬跨和插入反应中骨盆推撞的频率，而与鞘内注射生理盐水时获得的值相比，α2-肾上腺素能受体激动剂可乐定（25微克）和β-肾上腺素能受体激动剂异丙肾上腺素（40微克）均降低了这些反应中骨盆推撞的频率。另一方面，推撞序列的持续时间以及爬跨和插入时骨盆推撞的强度或力度与生理盐水处理时获得的值没有差异。这些发现表明去甲肾上腺素可能参与调节雄性大鼠交配时产生有节奏骨盆推撞所涉及的脊髓机制。
