Tseng C H, Chong C K, Lin B J, Chen C J, Tai T Y
Department of Internal Medicine, National Taiwan University Hospital, Taipei, R.O.C.
J Formos Med Assoc. 1994 Aug;93(8):663-7.
The purpose of this study was to evaluate risk factors associated with peripheral vascular disease (PVD) in patients with non-insulin-dependent diabetes mellitus (NIDDM). A group of 100 patients (50 men and 50 women) aged 50 years or over with PVD and another group of 200 age-sex-matched patients (100 men and 100 women) without PVD were studied. The mean +/- standard error of ages for subjects with and without PVD were 60.8 +/- 0.6 years and 59.7 +/- 0.3 years, respectively. Doppler ultrasound was used to measure the systolic pressures of the brachial, posterior tibial and dorsal pedal arteries bilaterally. The diagnosis of PVD was made by an ankle-brachial index (ABI) < 0.90 and the diagnosis of non-PVD by an ABI > 1.00. The association of PVD with diabetic duration, body mass index (BMI), cerebral infarction (CI), coronary heart disease (CHD), proteinuria, diabetic retinopathy, neuropathy, hypertension, and cigarette smoking was evaluated. In addition, biochemical data including fasting plasma glucose, hemoglobin (HD)Alc, cholesterol, triacylglycerol, high- and low-density lipoprotein cholesterol, uric acid, blood urea nitrogen (BUN) and creatinine (Cr) were studied. In univariate analysis, PVD was associated with an increased level of systolic blood pressure (SBP), BUN and Cr, cigarette smoking, CI, CHD, proteinuria and retinopathy. In stepwise logistic regression analysis, the level of SBP, cigarette smoking and CI remained statistically significant. The log odds of PVD could be expressed as: -2.834 + 0.013 (SBP in mmHg) + 0.577 (cigarette smoking) + 1.320 (CI). PVD is the result of aggregation of atherosclerotic risk factors; among those factors noted in this study, SBP, cigarette smoking and CI are important.
本研究旨在评估非胰岛素依赖型糖尿病（NIDDM）患者外周血管疾病（PVD）的相关危险因素。对一组100例年龄50岁及以上的PVD患者（50例男性和50例女性）以及另一组200例年龄和性别匹配的无PVD患者（100例男性和100例女性）进行了研究。有PVD和无PVD受试者的年龄均值±标准误分别为60.8±0.6岁和59.7±0.3岁。采用多普勒超声双侧测量肱动脉、胫后动脉和足背动脉的收缩压。PVD的诊断依据为踝臂指数（ABI）<0.90，非PVD的诊断依据为ABI>1.00。评估了PVD与糖尿病病程、体重指数（BMI）、脑梗死（CI）、冠心病（CHD）、蛋白尿、糖尿病视网膜病变、神经病变、高血压和吸烟之间的关联。此外，还研究了包括空腹血糖、糖化血红蛋白（HD）Alc、胆固醇、三酰甘油、高密度和低密度脂蛋白胆固醇、尿酸、血尿素氮（BUN）和肌酐（Cr）在内的生化数据。在单因素分析中，PVD与收缩压（SBP）、BUN和Cr水平升高、吸烟、CI、CHD、蛋白尿和视网膜病变相关。在逐步逻辑回归分析中，SBP水平、吸烟和CI仍具有统计学意义。PVD的对数几率可表示为：-2.834 + 0.013（SBP，单位为mmHg）+ 0.577（吸烟）+ 1.320（CI）。PVD是动脉粥样硬化危险因素聚集的结果；在本研究中指出的那些因素中，SBP、吸烟和CI很重要。
