Lin P W, Shan Y S
Department of Surgery, Medical College, National Cheng-Kung University, Tainan, Taiwan, R.O.C.
J Formos Med Assoc. 1994 Aug;93(8):668-72.
This study was designed to investigate the effect of octreotide (Sandostatin, Sandoz), an analogue of somatostatin, on the hemodynamics and glucagon level in portal hypertension. Sixteen portal hypertensive rabbits produced by partial ligation of the portal vein two weeks earlier received an intravenous infusion of octreotide at a dose of 30 micrograms/h. After infusion of octreotide, a significant reduction in portal venous pressure from 16.2 +/- 3.9 mmHg (mean +/- SD) to 13.3 +/- 4.3 mmHg at 21 minutes and 12.0 +/- 4.5 mmHg 42 minutes was noted. A persistent decrease in portal pressure to 11.0 +/- 4.5 mmHg 21 minutes after stopping infusion of octreotide was also observed. Portal venous blood flow was decreased significantly from 60.9 +/- 13.1 mL/min to 46.9 +/- 15.0 ml/min at 21 minutes and to 45.8 +/- 12.8 ml/min at 42 minutes. A slight elevation of portal blood flow to 49.0 +/- 14.1 ml/min was noted 21 minutes after cessation of octreotide infusion. Portal venous resistance was slightly elevated during infusion of octreotide (before infusion: 2.2 +/- 1.4 dyne.s.cm-5, 21 minutes after infusion: 2.4 +/- 1.4 dyne.s.cm-5 and 42 minutes after infusion: 2.3 +/- 1.3 dyne.s.cm-5), and decreased (1.9 +/- 1.0 dyne.s.cm-5, p < 0.1) with a forward significance after stopping infusion. There were no significant changes in systemic arterial pressure during this experiment. A significant decrease (p < 0.05) in glucagon level from 323 +/- 93 pg/dl to 267 +/- 62 pg/dl at 21 minutes and to 298 +/- 88 pg/dl at 42 minutes in the portal vein was noted during the infusion.(ABSTRACT TRUNCATED AT 250 WORDS)
本研究旨在探讨生长抑素类似物奥曲肽（善得定，山德士公司生产）对门静脉高压症血流动力学及胰高血糖素水平的影响。16只两周前通过部分结扎门静脉制成门静脉高压症的家兔，以30微克/小时的剂量静脉输注奥曲肽。输注奥曲肽后，门静脉压力显著降低，21分钟时从16.2±3.9毫米汞柱（平均值±标准差）降至13.3±4.3毫米汞柱，42分钟时降至12.0±4.5毫米汞柱。停止输注奥曲肽21分钟后，门静脉压力持续下降至11.0±4.5毫米汞柱。门静脉血流量在21分钟时从60.9±13.1毫升/分钟显著降至46.9±15.0毫升/分钟，42分钟时降至45.8±12.8毫升/分钟。停止输注奥曲肽21分钟后，门静脉血流量略有升高至49.0±14.1毫升/分钟。输注奥曲肽期间门静脉阻力略有升高（输注前：2.2±1.4达因·秒·厘米⁻⁵，输注后21分钟：2.4±1.4达因·秒·厘米⁻⁵，输注后42分钟：2.3±1.3达因·秒·厘米⁻⁵），停止输注后显著降低（1.9±1.0达因·秒·厘米⁻⁵，p<0.1）。实验期间体循环动脉压无显著变化。输注期间门静脉内胰高血糖素水平显著降低（p<0.05），21分钟时从323±93皮克/分升降至267±62皮克/分升，42分钟时降至298±88皮克/分升。（摘要截于250字）
