Kjaer A, Knigge U, Matzen S, Warberg J
Department of Medical Physiology, Panum Institute, University of Copenhagen, Denmark.
Eur J Endocrinol. 1995 Feb;132(2):223-8. doi: 10.1530/eje.0.1320223.
The neurotransmitter histamine (HA) is involved in central regulation of secretion of prolactin (PRL) and the proopiomelanocortin (POMC)-derived peptides adrenocorticotropin (ACTH), beta-endorphin (beta-END) and alpha-melanocyte-stimulating hormone (alpha-MSH). The effect of HA on POMC-derived peptides and PRL release is, at least in part, indirect and may involve activation of catecholaminergic systems. Therefore, we investigated the effect of beta-adrenergic receptor blockade on HA or HA agonist-induced release of ACTH, beta-END, alpha-MSH and PRL. Central administration of HA, the H1-receptor agonist 2-thiazolylethylamine (2-TEA) or the H2-receptor agonist 4-methylhistamine (4-MeHA) stimulated the secretion of ACTH, beta-END, alpha-MSH and PRL. Pretreatment with the beta-adrenergic antagonist propranolol inhibited secretion of the POMC peptides in response to HA, 2-TEA or 4-MeHA. Propranonol only inhibited the PRL response to HA or 2-TEA, but had no effect on the PRL response to 4-MeHA. Administration of the beta-receptor agonist isoproterenol stimulated ACTH, beta-END, alpha-MSH and PRL two to five-fold. This effect was totally blocked by pretreatment with propranolol. We conclude that HA-induced secretion of POMC-derived peptides from the anterior and intermediate lobe of the pituitary gland and of PRL from the anterior lobe is, at least in part, mediated via catecholamines. beta-Adrenergic receptors are involved in the mediation of the POMC response to H1- as well as H2-receptor activation, whereas beta-receptors are involved only in the mediation of the PRL response to H1-receptor activation.
神经递质组胺（HA）参与催乳素（PRL）分泌以及阿片-促黑素细胞皮质素原（POMC）衍生肽促肾上腺皮质激素（ACTH）、β-内啡肽（β-END）和α-黑素细胞刺激素（α-MSH）分泌的中枢调节。HA对POMC衍生肽和PRL释放的作用至少部分是间接的，可能涉及儿茶酚胺能系统的激活。因此，我们研究了β-肾上腺素能受体阻断对HA或HA激动剂诱导的ACTH、β-END、α-MSH和PRL释放的影响。向中枢给予HA、H1受体激动剂2-噻唑基乙胺（2-TEA）或H2受体激动剂4-甲基组胺（4-MeHA）可刺激ACTH、β-END、α-MSH和PRL的分泌。用β-肾上腺素能拮抗剂普萘洛尔预处理可抑制POMC肽对HA、2-TEA或4-MeHA的分泌反应。普萘洛尔仅抑制PRL对HA或2-TEA的反应，但对PRL对4-MeHA的反应无影响。给予β受体激动剂异丙肾上腺素可使ACTH、β-END、α-MSH和PRL的分泌增加2至5倍。普萘洛尔预处理可完全阻断此效应。我们得出结论，HA诱导垂体前叶和中叶POMC衍生肽的分泌以及前叶PRL的分泌至少部分是通过儿茶酚胺介导的。β-肾上腺素能受体参与POMC对H1以及H2受体激活的反应介导，而β受体仅参与PRL对H1受体激活的反应介导。
