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[急性细菌性痢疾患者大肠黏膜中的含抗体细胞]

[Antibody-containing cells in the mucosa of the large intestine of patients with acute bacterial dysentery].

作者信息

Shalygina N B, Petrova T P, Iushchuk N D

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1976 Jan(1):53-6.

PMID:785886
Abstract

The authors traced the dynamics of appearance, increase and disappearance of O-antibody-containing cells in the mucosa of the distal portion of the large intestine in patients suffering from acute Sonne and Flexner dysentery (aspiration biopsy of the mucosa). The antibodies were revealed by the indirect Coons method. The total number of cells per 1 mm2 of 4 mum of the mucosal section the number of lymphoid cells and the content of the antibody-containing cells in % per total cell count of the lymphoid tissue was calculated. It was revealed that the antibody-containing cells appeared on the 4th day of the disease, reached the maximum on the 7th--8th and disappeared on the 22nd--25th day. Cells of the plasmocytic series containing no antidysentery antibodies, were revealed in large amounts even at the remote periods (up to 6 months) after recovery.

摘要

作者追踪了患急性宋内氏和福氏痢疾患者大肠远端黏膜中含O抗体细胞的出现、增多及消失动态(黏膜吸引活检)。采用间接孔斯法检测抗体。计算每1平方毫米黏膜切片4微米厚度内的细胞总数、淋巴细胞数量以及含抗体细胞在淋巴细胞组织总细胞计数中所占的百分比。结果显示,含抗体细胞在疾病第4天出现,第7 - 8天达到峰值,第22 - 25天消失。即使在康复后的远期(长达6个月),仍大量存在不含抗痢疾抗体的浆细胞系细胞。

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