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应激、抗抑郁药物与蓝斑核。

Stress, antidepressant drugs, and the locus coeruleus.

作者信息

Brady L S

机构信息

Section on Functional Neuroanatomy, NIMH, Bethesda, MD 20892.

出版信息

Brain Res Bull. 1994;35(5-6):545-56. doi: 10.1016/0361-9230(94)90168-6.

DOI:10.1016/0361-9230(94)90168-6
PMID:7859112
Abstract

This review presents a synthesis of a large body of seemingly inconsistent literature on the role of the locus coeruleus-norepinephrine (LC-NE) system and the corticotropin-releasing hormone (CRH)-median eminence system in mediating the CNS effects of stress and the therapeutic effects of antidepressant drugs. The clinical implications of these findings for the etiology and treatment of stress-related psychiatric disorders such as depression will be discussed.

摘要

本综述对大量关于蓝斑去甲肾上腺素（LC-NE）系统和促肾上腺皮质激素释放激素（CRH）-正中隆起系统在介导应激的中枢神经系统效应及抗抑郁药物治疗作用方面看似相互矛盾的文献进行了综合分析。将讨论这些发现对诸如抑郁症等与应激相关的精神障碍的病因学和治疗的临床意义。

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