Kumar S, Khanna S S
Acta Anat (Basel). 1976;94(1):30-9. doi: 10.1159/000144542.
Glucose evoked significant hyperglycemia in the frog, Rana tigrina, 0.5 h after the injection and it took a longer time to regain normoglycemia than mammals, thus exhibiting a low glucose tolerance. The islet tissue of injected animals showed degranulation and atrophy of beta-cells only, the alpha-cells remained almost normal. This damage suggests that the beta-cells of this frog are functionally like those of mammals and other vertebrates, and secrete insulin. A single dose of glucose was found incapable of producing permanent diabetes, and beta-cells damage was repairable at later stages. Excess of glucose in the blood seems to stimulate secretion of insulin by the beta-cells.
注射葡萄糖0.5小时后，在虎纹蛙体内引发了显著的高血糖，恢复正常血糖水平所需的时间比哺乳动物更长，因此表现出较低的葡萄糖耐受性。注射动物的胰岛组织仅显示β细胞脱粒和萎缩，α细胞几乎保持正常。这种损伤表明，这种青蛙的β细胞在功能上与哺乳动物和其他脊椎动物的β细胞相似，并且分泌胰岛素。发现单剂量葡萄糖无法导致永久性糖尿病，且β细胞损伤在后期是可修复的。血液中过量的葡萄糖似乎会刺激β细胞分泌胰岛素。
