Kumar S
Z Mikrosk Anat Forsch. 1976;90(4):633-40.
The effect of mammalian crystalline glucagon (0.5 mg and 2.0 mg/kg) on the blood glucose level and pancreatic islets of Rana tigrina was studied at different stages after its treatment. This frog is moderately sensitive to glucagon and exhibits hyperglycemia and regressive changes, primarily in the beta- and secondarily in the alpha-cells of the islet tissue. The effectiveness of the hormone depends upon the dose employed. The restricted damage in only a fraction of the alpha-cells indicates that this fraction is like the glucagon secreting alpha2-cells of mammals and is the source of glucagon in Rana tigrina also.
研究了哺乳动物结晶胰高血糖素（0.5毫克/千克和2.0毫克/千克）对虎纹蛙治疗后不同阶段血糖水平和胰岛的影响。这种青蛙对胰高血糖素中度敏感，表现为高血糖和退行性变化，主要发生在胰岛组织的β细胞，其次是α细胞。激素的有效性取决于所用剂量。仅一小部分α细胞受到有限损伤，这表明这部分细胞类似于哺乳动物分泌胰高血糖素的α2细胞，也是虎纹蛙胰高血糖素的来源。
