Yamawaki I, Bukovac S W, Sunami A
Tokushima Research Center, Pharmacokinetics Research Lab., Japan.
Chem Pharm Bull (Tokyo). 1994 Nov;42(11):2365-9. doi: 10.1248/cpb.42.2365.
Five metabolites of syn-3-ethyl-7-methyl-3,7-diazabicyclo[3.3.1]non-9-yl 4-chlorobenzoate hydrochloride (YUTAC) (1) were prepared and examined for Na+ current blocking activity in guinea pig ventricular myocytes. These metabolites showed lower inhibitory activities than the parent compound or were inactive.
制备了盐酸顺式-3-乙基-7-甲基-3,7-二氮杂双环[3.3.1]壬-9-基4-氯苯甲酸酯（YUTAC）（1）的五种代谢物，并在豚鼠心室肌细胞中检测了它们对钠离子电流的阻断活性。这些代谢物的抑制活性低于母体化合物，或无活性。
