Dissolution behavior of phenytoin-bile salt complexes prepared by co-grinding.

The physicochemical properties of phenytoin (PHT)-bile salt complexes comprised of sodium dehydrocholate (DHCNa), sodium deoxycholate (DCNa) or sodium cholate (CNa) prepared by co-grinding were investigated by X-ray diffraction analysis, DSC and dissolution kinetics. All X-ray diffraction peak intensities of the co-ground PHT-bile salt [1 mol: 1 mol] mixtures were decreased by grinding for 3 h, and showed a halo pattern of a noncrystalline solid. The solubility of ground products with DCNa, DHCNa and CNa were 212, 56, 68 times higher, respectively, than those of physical mixtures.