Schilling W, Svehag S E
Acta Pathol Microbiol Scand C. 1976 Aug;84(4):325-32. doi: 10.1111/j.1699-0463.1976.tb00037.x.
Heterotopic grafting of split allogeneic mouse hearts across a strong H-2 barrier (A/Sn leads to A.CA) was used in a study of alloantibody or F (ab')2 induced enhancement. Strong specific binding of alloantibodies occurred in the graft. A marked synergistic effect on graft survival was observed after combined treatment of recipients with enhancing serum and prednisone. The highly dose-dependent enhancing effect of F (ab')2 was also strongly potentiated by supporting prednisone treatment. In vitro pre-incubation of the heart tissue with alloantiserum or F (ab')2 did not prolong graft survival; in contrast, C-mediated damage of the graft was suggested when serum was used.
在一项关于同种抗体或F（ab'）2诱导增强作用的研究中，采用了跨越强大H-2屏障（A/Sn至A.CA）的同种异体小鼠心脏异位移植。在移植物中发生了同种抗体的强特异性结合。在用增强血清和泼尼松联合治疗受体后，观察到对移植物存活有显著的协同作用。支持性泼尼松治疗也强烈增强了F（ab'）2的高度剂量依赖性增强作用。心脏组织与同种抗血清或F（ab'）2的体外预孵育并未延长移植物存活时间；相反，当使用血清时，提示移植物有补体介导的损伤。
