Frangos E, Christodoulides H
Acta Psychiatr Belg. 1975 Jan;75(1):19-32.
In the present study, after briefly describing the clinical characteristics of the neurologic syndromes provoked by the neuroleptic drugs and most particularly of the syndrome of tardive dyskinesia, we refer to the incidence of this latter syndrome and to the results obtained with the administration of haloperidol for a period of 16 weeks in 10 patients suffering from it. From the detailed analysis of 300 chronic schizophrenic patients, we detected this complication in 10 cases, which gives an incidence of 3,3%. With the administration of haloperidol, on the other hand, we obtained an excellent reduction of both the frequency and the intensity of the peristomal movements in nearly all the patients. This reduction was more remarkable in 2 of the patients who had manifested certain complications of the syndrome, mainly a difficulty in swallowing, followed by a considerable loss of weight in the one patient and by an intense perplexity and a tendency towards suicide in the other. The continued suppression of the above dyskinetic phenomena during the whole period of the trial allows us to conclude that haloperidal may be recommended for the maintenance treatment of the syndrome of tardive dyskinesia.
在本研究中，我们首先简要描述了抗精神病药物引发的神经综合征的临床特征，尤其是迟发性运动障碍综合征的特征，接着提到了该综合征的发病率，以及对10例患有迟发性运动障碍综合征的患者给予氟哌啶醇治疗16周所取得的结果。通过对300例慢性精神分裂症患者的详细分析，我们在10例患者中检测到了这种并发症，发病率为3.3%。另一方面，通过给予氟哌啶醇治疗，几乎所有患者的口周运动频率和强度都得到了显著降低。在2例出现该综合征某些并发症的患者中，这种降低更为明显，主要表现为吞咽困难，其中1例患者体重明显减轻，另1例患者则表现出强烈的困惑和自杀倾向。在整个试验期间，上述运动障碍现象持续得到抑制，这使我们得出结论，氟哌啶醇可推荐用于迟发性运动障碍综合征的维持治疗。
