Kadowaki T, Yoshinaga H
Third Department of Internal Medicine, University of Tokyo, Japan.
Diabetes Res Clin Pract. 1994 Oct;24 Suppl:S123-7. doi: 10.1016/0168-8227(94)90238-0.
Follow-up studies of subjects with impaired glucose tolerance in Japan have shown that a higher level of blood glucose is a major predictor of the subsequent development of non-insulin-dependent diabetes mellitus (NIDDM). In addition, subjects with a lower insulin response to glucose show a higher risk for the development of NIDDM. In fact, most of the subjects who later develop diabetes show a lower insulin response to glucose at the initial examination. Moreover, obesity is generally associated with a higher risk of developing NIDDM. We conclude that low insulin secretion forms an important basis and obesity plays a precipitating role among low-insulin responders in the pathogenesis of the majority of NIDDM patients in Japan.
日本针对糖耐量受损人群的后续研究表明，较高的血糖水平是随后发生非胰岛素依赖型糖尿病（NIDDM）的主要预测指标。此外，对葡萄糖的胰岛素反应较低的人群患NIDDM的风险更高。事实上，大多数后来患糖尿病的人在初次检查时对葡萄糖的胰岛素反应较低。此外，肥胖通常与患NIDDM的较高风险相关。我们得出结论，在日本大多数NIDDM患者的发病机制中，胰岛素分泌不足是一个重要基础，而肥胖在胰岛素反应低的人群中起促发作用。
