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[土拉菌病抗体红细胞诊断试剂检测特异性抗原及针对该抗原的抗体的有效性]

[Effectiveness of the tularemia-antibody erythrocyte diagnostic agent for the detection of specific antigen and antibodies to it].

作者信息

Shmuter M F, Aĭkimbaev M A, Eliubaeva A M, Brikman D I, Charnaia E F

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1978 Feb(2):61-4.

PMID:78604
Abstract

The authors demonstrated the efficacy of utilization of tularemia antibody erythrocytic diagnostic agent. Data are presented indicating a strict specificity and a high sensitivity of this diagnostic agent for detection of the Vi-antigen both in the tularemia microbe cultures and in the suspensions of the organs of rodents which perished of tularemia, irrespective of the state of cadaver. There was revealed relationship between the sensitivity of the diagnostic agent and the virulence of the tularemia microbe cultures. A possibility of using the diagnostic agent in the antigen neutralization test for detection of specific antibodies in the sera of patients, who sustained the disease, and of the vaccinated humans and animals was revealed.

摘要

作者展示了土拉菌病抗体红细胞诊断剂的应用效果。所呈现的数据表明,该诊断剂在检测土拉菌病微生物培养物以及死于土拉菌病的啮齿动物器官悬液中的Vi抗原时,无论尸体状态如何,都具有严格的特异性和高灵敏度。还发现了诊断剂的灵敏度与土拉菌病微生物培养物毒力之间的关系。揭示了该诊断剂在抗原中和试验中用于检测患病患者以及接种疫苗的人和动物血清中特异性抗体的可能性。

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