van Oosterhout A G, Boon P J, Houx P J, ten Velde G P, Twijnstra A
Department of Neurology, University Hospital Maastricht, The Netherlands.
Int J Radiat Oncol Biol Phys. 1995 Feb 15;31(4):911-4. doi: 10.1016/0360-3016(94)00579-6.
Study of the course of possible treatment-related cognitive impairment in patients with small cell lung cancer.
Thirty-two consecutive patients with small cell lung cancer underwent successive neurologic and neuropsychologic examinations until 5 months after prophylactic cranial irradiation, and in their pretherapeutic condition were compared to matched controls. Patients with brain metastases were excluded from this study.
Neurologic examination revealed central nervous system (CNS) abnormalities only in the 14 patients with brain metastases. In the remaining patients, neuropsychologic tests showed clear differences between the pretherapeutic performance of patients and that of matched controls (p < 0.001), but no significant deterioration either during or after therapy (0.1 < p < 0.8).
The difference between the pretherapeutic performance of patients and that of matched controls may indicate disease-related cognitive impairment. Within the observation period, no adverse effects of the used therapy were found. Our observations underline the importance of a pretherapeutic assessment in neurotoxicity research.
研究小细胞肺癌患者可能出现的与治疗相关的认知障碍病程。
32例连续的小细胞肺癌患者接受了连续的神经学和神经心理学检查，直至预防性颅脑照射后5个月，并将其治疗前状况与匹配的对照组进行比较。脑转移患者被排除在本研究之外。
神经学检查仅在14例脑转移患者中发现中枢神经系统（CNS）异常。在其余患者中，神经心理学测试显示患者治疗前表现与匹配对照组之间存在明显差异（p < 0.001），但治疗期间或治疗后均无显著恶化（0.1 < p < 0.8）。
患者治疗前表现与匹配对照组之间的差异可能表明与疾病相关的认知障碍。在观察期内，未发现所用治疗的不良反应。我们的观察结果强调了治疗前评估在神经毒性研究中的重要性。
