Rossi E C
Department of Medicine, Northwestern University Medical School, Chicago, Illinois.
Hematol Oncol Clin North Am. 1994 Dec;8(6):1045-52.
This article discusses anemia, the evaluation of symptoms, and the compensatory mechanisms that are brought into play by chronic anemia. The oxygen dissociation curve is described as is the effect of 2,3-DPG on hemoglobin-oxygen binding. Human tolerance to anemia is discussed and the article concludes with proposed transfusion strategies in chronic anemia.