来自枯草芽孢杆菌的芽孢形成蛋白SpoIVFB在没有其他芽孢形成基因产物的情况下可增强σ因子前体Pro-σK的加工。
Sporulation protein SpoIVFB from Bacillus subtilis enhances processing of the sigma factor precursor Pro-sigma K in the absence of other sporulation gene products.
作者信息
Lu S, Cutting S, Kroos L
机构信息
Department of Biochemistry, Michigan State University, East Lansing 48824.
出版信息
J Bacteriol. 1995 Feb;177(4):1082-5. doi: 10.1128/jb.177.4.1082-1085.1995.
Abstract
Processing of inactive pro-sigma K to active sigma K in the mother cell compartment of sporulating Bacillus subtilis is governed by a signal transduction pathway emanating from the forespore and involving SpoIVFB in the mother cell. Coexpression of spoIVFB and sigK (encoding pro-sigma K) genes in growing B. subtilis or Escherichia coli enhanced pro-sigma K processing in the absence of other sporulation-specific gene products. The simplest explanation of these results is that SpoIVFB is a protease that processes pro-sigma K.
摘要
在枯草芽孢杆菌芽孢形成过程中，母细胞区室中无活性的前σK加工成活性σK是由从前芽孢发出并涉及母细胞中SpoIVFB的信号转导途径控制的。在生长的枯草芽孢杆菌或大肠杆菌中共表达spoIVFB和sigK（编码前σK）基因，在没有其他芽孢形成特异性基因产物的情况下增强了前σK的加工。对这些结果最简单的解释是SpoIVFB是一种加工前σK的蛋白酶。
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