Irwin L R
Department of Neurosurgery, Newcastle General Hospital, Newcastle-upon-Tyne, UK.
J R Coll Surg Edinb. 1994 Oct;39(5):292-4.
This retrospective study looks at the severe head injury patients admitted to one unit in a year. Within this group, those with significant gastrointestinal bleeding were further studied to assess medical prophylaxis against this complication. A preliminary attempt is made to gauge whether such medication is appropriate, particularly with reference to H-2 antagonists. No firm conclusions can be drawn, but sufficient doubt remains to justify a prospective trial which is planned.
这项回顾性研究观察了一年内收治于某科室的重型颅脑损伤患者。在该组患者中,对发生严重胃肠道出血的患者进一步研究,以评估针对这一并发症的药物预防措施。初步尝试判断此类药物是否合适,尤其是针对H2拮抗剂。目前尚无法得出确切结论,但仍存在足够疑问,有必要开展一项已计划好的前瞻性试验。