Pu Y M, Ziffer H
Laboratory of Chemical Physics, NIDDK, Bethesda, Maryland 20892-0510.
J Med Chem. 1995 Feb 17;38(4):613-6. doi: 10.1021/jm00004a007.
Synthesis of 12 beta-allyldeoxoartemisinin from dihydroartemisinin and subsequent transformations to other 12 beta-alkyldeoxoartemisinins are described. All compounds were tested in vitro versus two drug-resistant strains (Plasmodium falciparum) of malaria. The in vivo activity and toxicity of the most active compound, 12 beta-propyldeoxoartemisinin, were comparable to that of arteether.
