Niizuma K
Acta Derm Venereol. 1976;56(5):327-36.
Light microscopic and electron microscopic studies of a lesion displaying a typical histopathological picture of syringocystadenoma papilliferum (S.P.) are reported. Light microscopic serial sections showed that the tumor parenchyma extended to the epithelium just above the intrafollicular sebaceous duct. The tumor thus presumably develops from the epithelial region corresponding to the intrafollicular duct of the apocrine sweat gland. Electron microscopy revealed a non-keratinized intracytoplasmic cavity and intercellular canaliculi apparently formed as a continuation of this cavity. Keratinized cells were absent from the glandular and duct epithelium and even from the superficial epithelial portion of acanthotic areas. Neither myoepithelial cells nor secretory granules were identified in areas showing tubular, glandular, or sinusoidal structures. It was concluded that the tumor differentiates towards both the intrafollicular and intradermal duct of the embryonic apocrine sweat gland apparatus.
本文报告了对一个呈现典型乳头状汗腺囊腺瘤（S.P.）组织病理学图像的病变进行的光镜和电镜研究。光镜连续切片显示肿瘤实质延伸至毛囊内皮脂腺导管上方的上皮。因此，该肿瘤可能起源于与顶泌汗腺毛囊内导管相对应的上皮区域。电镜观察发现一个非角化的胞浆内腔隙以及明显作为该腔隙延续的细胞间小管。腺上皮和导管上皮甚至棘层增厚区域的浅表上皮部分均未见角化细胞。在呈现管状、腺状或窦状结构的区域未发现肌上皮细胞和分泌颗粒。得出的结论是，该肿瘤向胚胎顶泌汗腺装置的毛囊内和真皮内导管分化。
