2-甲基-5-羟色胺通过α1-肾上腺素能受体介导的兔颈总动脉血管收缩。

2-Methyl-5-HT-induced vasoconstrictions mediated via alpha 1-adrenoceptors in rabbit common carotid arteries.

作者信息

Fujiwara T, Chiba S

机构信息

Department of Pharmacology, Shinshu University School of Medicine, Matsumoto, Japan.

出版信息

Jpn J Pharmacol. 1994 Sep;66(1):155-7. doi: 10.1254/jjp.66.155.

DOI:10.1254/jjp.66.155

PMID:7861662

Abstract

We investigated the effects of 2-methyl-5-HT and 1-phenylbiguanide on isolated and perfused rabbit common carotid arteries by a cannula insertion method. 1-Phenylbiguanide produced neither vasoconstriction nor dilation. On the other hand, 2-methyl-5-HT produced only a vasoconstriction, and the dose-response curve was shifted to the right in parallel by treatment with either ketanserin or bunazosin, although methysergide and granisetron had no antagonistic effect. Moreover, the vasoconstriction was not inhibited by guanethidine and imipramine. These data showed that 2-methyl-5-HT acts as an alpha 1-adrenoceptor agonist but not as a 5-HT3-receptor agonist in this vessel.

摘要

我们通过插管法研究了2-甲基-5-羟色胺和1-苯基双胍对离体灌注兔颈总动脉的影响。1-苯基双胍既不引起血管收缩也不引起血管舒张。另一方面，2-甲基-5-羟色胺仅引起血管收缩，用酮色林或布那唑嗪处理后，剂量-反应曲线平行右移，而麦角新碱和格拉司琼无拮抗作用。此外，胍乙啶和丙咪嗪不能抑制这种血管收缩。这些数据表明，在该血管中，2-甲基-5-羟色胺作为α1肾上腺素能受体激动剂起作用，而不是作为5-HT3受体激动剂起作用。