Chen T S, Drutz D J, Whelan G E
Arch Pathol Lab Med. 1976 Apr;100(4):182-5.
A clinicopathologic study of liver disease was conducted on 28 patients with leprosy who lived in Taiwan. None of the patients exhibited symptoms or signs of liver disease. Hepatic granulomas were found in 21 patients. Histologically, the infiltrates were epithelioid, foam cell, and histiocytic in type. Hepatic dysfunction was absent, except for mild sulfobromophthalein elevations in the severely infected cases. Hepatic granulomas correlated with the cutaneous reactions in lepromatous leprosy, but the association was poor for other stages of disease. Hepatic involvement varied with the severity of cutaneous infection and with the frequency and intensity of bacteremia. An estimated 1,000 to 10,000 acid-fast bacilli/ml of blood was required to generate the hepatic infiltrates.
对居住在台湾的28例麻风患者进行了肝病的临床病理研究。所有患者均无肝病症状或体征。21例患者发现肝脏肉芽肿。组织学上，浸润类型为上皮样、泡沫细胞和组织细胞。除严重感染病例中轻度磺溴酞钠升高外，无肝功能障碍。肝脏肉芽肿与瘤型麻风的皮肤反应相关，但在疾病的其他阶段相关性较差。肝脏受累程度随皮肤感染的严重程度以及菌血症的频率和强度而变化。估计每毫升血液中有1000至10000条抗酸杆菌才能产生肝脏浸润。
