Boonpucknavig V, Bhamarapravati N, Boonpucknavig S, Futrakul P, Tanpaichitr P
Arch Pathol Lab Med. 1976 Apr;100(4):206-12.
Percutaneous needle biopsies were performed on the kidneys of 20 patients who had dengue hemorrhagic fever with some clinical manifestation of renal impairment. In ten cases IgG or IgM, or both, and C3 could be localized in the glomeruli, using the fluorescent antibody technique. In those cases in which immune complex was found, the biopsy had been done in the second week after the onset of fever. Electron microscopy showed focal thickening of the glomerular basement membrane, with hypertrophy of mesangial cells at the sites where the immune complex was shown. Dense, spherical particles, 40 to 50 nm in diameter, were found in 12 cases. Those particles were carried into the glomeruli by monocyte-like cells.
对20例有登革出血热且伴有肾功能损害临床表现的患者进行了经皮肾穿刺活检。采用荧光抗体技术，在10例患者的肾小球中可定位出IgG或IgM，或两者均有，以及C3。在发现免疫复合物的病例中，活检是在发热开始后的第二周进行的。电子显微镜检查显示肾小球基底膜局灶性增厚，在显示免疫复合物的部位系膜细胞肥大。在12例病例中发现了直径为40至50纳米的致密球形颗粒。这些颗粒由单核细胞样细胞带入肾小球。
