Axelrod O, Klaus S, Frankenburg S
Department of Dermatology, Hadassah Medical Organization, Jerusalem, Israel.
Parasite Immunol. 1994 Nov;16(11):593-8. doi: 10.1111/j.1365-3024.1994.tb00315.x.
Cutaneous leishmaniasis is a disease induced by intradermal injection of leishmania promastigotes. Since the first cells the parasite encounters are those of the skin, the involvement of this organ in the early immune response might be relevant to the outcome of the disease. In this study we examined the ability of epidermal langerhans cells (LC) to become infected in vivo and to function as antigen presenting cells during the early hours of infection with Leishmania major. Our experiments showed that LC from mice injected with parasites can present antigen to a leishmania-specific T cell line when LC are obtained as early as four h after infection. The stimulation was specific, since LC from leishmania injected mice did not present antigen to an ovalbumin-specific T cell line nor did LC from ovalbumin-injected mice present antigen to the leishmania specific T cell line. Despite the ability of epidermal LC cells to present antigen, no parasites were detected in the epidermis, suggesting that these cells are not directly involved in establishing an infection.
皮肤利什曼病是一种由皮内注射利什曼原鞭毛虫引起的疾病。由于寄生虫首先遇到的细胞是皮肤细胞，该器官在早期免疫反应中的参与可能与疾病的转归相关。在本研究中，我们检测了表皮朗格汉斯细胞（LC）在体内被感染以及在感染硕大利什曼原虫早期作为抗原呈递细胞发挥功能的能力。我们的实验表明，在感染后早至4小时获取的情况下，来自注射寄生虫小鼠的LC能够将抗原呈递给利什曼原虫特异性T细胞系。这种刺激是特异性的，因为来自注射利什曼原虫小鼠的LC不会将抗原呈递给卵清蛋白特异性T细胞系，注射卵清蛋白小鼠的LC也不会将抗原呈递给利什曼原虫特异性T细胞系。尽管表皮LC细胞有呈递抗原的能力，但在表皮中未检测到寄生虫，这表明这些细胞不直接参与建立感染。
