迟发性运动障碍病理生理学潜在的遗传因素。

Possible genetic factors underlying the pathophysiology of tardive dyskinesia.

作者信息

Rosengarten H, Schweitzer J W, Friedhoff A J

机构信息

Millhauser Laboratories, Department of Psychiatry, New York University School of Medicine, NY 10016.

出版信息

Pharmacol Biochem Behav. 1994 Nov;49(3):663-7. doi: 10.1016/0091-3057(94)90085-x.

DOI:10.1016/0091-3057(94)90085-x

PMID:7862722

Abstract

Rates of spontaneous and drug-induced repetitive jaw movements (RJM) in rats vary widely. Low and high RJM responders were isolated and genetically selected. At each generation mean RJM responses (spontaneous or SKF 38393-induced) of the two types of rats were found to differ significantly, whereas neither apomorphine-induced stereotypic responses nor D1 and D2 receptor numbers and affinities differed. A significant increase in cAMP production was evident in SKF 38393-stimulated striatal homogenates of high RJM responders as compared with low responders. Animals subjected to 8-months exposure to fluphenazine exhibited RJM that were about twice as great as that of controls, 2 months after the last treatment, with a prevalence of about 75%. Similarities between RJM observed in rats and neuroleptic-induced tardive dyskinesia suggest that the two are strongly related.

摘要

大鼠自发和药物诱导的重复性下颌运动（RJM）发生率差异很大。对低RJM反应者和高RJM反应者进行了分离和基因筛选。在每一代中，发现这两种类型大鼠的平均RJM反应（自发或SKF 38393诱导）存在显著差异，而阿扑吗啡诱导的刻板反应以及D1和D2受体数量与亲和力均无差异。与低反应者相比，高RJM反应者经SKF 38393刺激的纹状体匀浆中cAMP生成显著增加。接受氟奋乃静8个月的动物在最后一次治疗后2个月出现的RJM约为对照组的两倍，患病率约为75%。在大鼠中观察到的RJM与抗精神病药物诱导的迟发性运动障碍之间的相似性表明两者密切相关。