Elhwuegi A S
Department of Pharmacology and Biochemistry, Faculty of Pharmacy, Al-Fateh Medical University, Tripoli, Libya.
Pharmacology. 1994 Nov;49(5):308-13. doi: 10.1159/000139247.
The hypnosis and hypothermia induced by phenobarbitone (100 mg/kg i.p.) were greatly potentiated by combined treatment with alpha-methylparatyrosine (alpha-MPT, 250 mg/kg i.p.). alpha-MPT per se produced sedation and hypothermia. Measurement of blood and brain levels of phenobarbitone in rats treated with phenobarbitone alone or phenobarbitone plus alpha-MPT revealed that the latter delayed the disappearance rates of phenobarbitone from both brain and plasma. These results suggest an interaction at the site of distribution, metabolism and/or excretion of phenobarbitone. The possibility of a pharmacodynamic interaction involving neurotransmitters is also discussed.
苯巴比妥（100毫克/千克腹腔注射）诱导的催眠和体温过低，通过与α-甲基对酪氨酸（α-MPT，250毫克/千克腹腔注射）联合治疗得到极大增强。α-MPT本身会产生镇静和体温过低作用。对单独给予苯巴比妥或苯巴比妥加α-MPT的大鼠进行苯巴比妥血药浓度和脑药浓度测量发现，后者延缓了苯巴比妥从脑和血浆中的消失速度。这些结果表明在苯巴比妥的分布、代谢和/或排泄部位存在相互作用。还讨论了涉及神经递质的药效学相互作用的可能性。
