维生素E或普罗布考作为过氧化物酶/H2O2氧化人低密度脂蛋白的供体。
Vitamin E or probucol as donors for oxidation of human low-density lipoprotein by peroxidases/H2O2.
作者信息
Braun S, von Bruchhausen F
机构信息
Institute of Pharmacology, Universitätsklinikum Rudolf Virchow, Free University, Berlin, Germany.
出版信息
Pharmacology. 1994 Nov;49(5):325-35. doi: 10.1159/000139250.
Horseradish peroxidase or myeloperoxidase and H2O2 oxidize human low-density lipoprotein (LDL) in the presence or absence of a xenobiotic donor without an essential lag phase as revealed by an increase in the absorption at 234 nm. In the latter case, natural antioxidants like vitamin E and congeners serve as donor; radical formation by the action of peroxidase has been described before. Otherwise trolox C or probucol have donor function in this system. After oxidation by peroxidase/H2O2 LDL showed the expected reduced antioxidant capacity against vitamin-E-consuming radicals.
辣根过氧化物酶或髓过氧化物酶以及过氧化氢在有或没有外源性供体存在的情况下，均可氧化人低密度脂蛋白（LDL），且不存在必需的延迟期，这可通过234nm处吸光度的增加得以揭示。在后一种情况下，天然抗氧化剂如维生素E及其同系物可作为供体；过氧化物酶作用下的自由基形成此前已有描述。此外，生育酚类似物C或普罗布考在该系统中具有供体功能。经过氧化物酶/过氧化氢氧化后，低密度脂蛋白对消耗维生素E的自由基的抗氧化能力降低，符合预期。
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