Fagerström K O, Pomerleau O, Giordani B, Stelson F
Pharmacia Research Laboratories, Helsingborg, Sweden.
Psychopharmacology (Berl). 1994 Sep;116(1):117-9. doi: 10.1007/BF02244882.
Two elderly patients with Parkinson's disease were treated with nicotine gum and patch. Reliable changes in symptomatology were noted, using a single-subject, placebo-control reversal design. Improvement was associated with active nicotine dosing and involved diminished tremor and disorganized thinking in one patient and diminished bradykinesia and increased energy in the other.
两名老年帕金森病患者接受了尼古丁口香糖和贴片治疗。采用单受试者、安慰剂对照反转设计,观察到症状有可靠变化。改善与活性尼古丁给药有关,其中一名患者震颤减轻、思维紊乱改善,另一名患者运动迟缓减轻、精力增加。