Zwiebel W J, Mountford R A, Halliwell M J, Wells P N
Department of Radiology, Veterans Administration Medical Center, Salt Lake City, UT 84148.
Radiology. 1995 Mar;194(3):807-12. doi: 10.1148/radiology.194.3.7862983.
To investigate splanchnic blood flow changes in patients with hepatic cirrhosis and portal hypertension.
Duplex Doppler ultrasound (US) was used to measure blood flow in the superior mesenteric artery (SMA) and splenic artery in 20 patients with biopsy-proved cirrhosis and clinical evidence of portal hypertension, and in 20 healthy volunteers who were matched for age and sex.
Mean SMA and splenic artery blood flow was significantly greater in the patients than in healthy subjects. Neither SMA nor splenic artery blood flow was increased in patients with normal-sized spleens; however, blood flow was significantly elevated in patients with splenomegaly. Total splanchnic blood flow in patients was also significantly elevated compared with healthy subjects. Total splanchnic blood flow in patients with normal-sized spleens was not significantly elevated compared with healthy subjects, but splanchnic flow was significantly increased in patients with splenomegaly.
Blood flow is increased in the SMAs and splenic arteries of patients with cirrhosis and portal hypertension. Increased splanchnic blood flow associated with cirrhosis may occur exclusively in patients with splenomegaly.
研究肝硬化和门静脉高压患者的内脏血流变化。
采用双功多普勒超声（US）测量20例经活检证实为肝硬化且有门静脉高压临床证据的患者以及20例年龄和性别相匹配的健康志愿者的肠系膜上动脉（SMA）和脾动脉血流。
患者的平均SMA和脾动脉血流显著高于健康受试者。脾脏大小正常的患者，SMA和脾动脉血流均未增加；然而，脾肿大患者的血流显著升高。与健康受试者相比，患者的总内脏血流也显著升高。脾脏大小正常的患者的总内脏血流与健康受试者相比无显著升高，但脾肿大患者的内脏血流显著增加。
肝硬化和门静脉高压患者的SMA和脾动脉血流增加。与肝硬化相关的内脏血流增加可能仅发生在脾肿大患者中。
