Ozawa T, Ninomiya Y, Honma T, Kikuchi M, Sato T, Nakano M, Arakawa M
Department of Medicine (II), Niigata University School of Medicine, Japan.
Scand J Rheumatol. 1995;24(1):38-43. doi: 10.3109/03009749509095153.
The relationship between serum angiotensin I-converting enzyme (ACE) activity, a possible marker of pulmonary endothelial injury, and the occurrence of pulmonary hypertension (PH) in patients with mixed connective tissue disease (MCTD) was investigated. Before corticsteroid therapy, the mean serum ACE level was 26.4 +/- 14.0 mU/ml in patients with MCTD and PH (n = 6), 16.8 +/- 4.1 mU/ml in patients with MCTD but without PH (n = 18), 16.8 +/- 4.1 mU/ml in patients with undifferentiated connective tissue disease (n = 14), and 16.5 +/- 3.9 mU/ml in controls (n = 18). No significant difference in the enzyme activity was found among the groups. However, 4 patients with MCTD showed increased ACE levels (> 28.3 mU/ml), and all of them had PH. Our results suggest that elevation of serum ACE activity may be related to the occurrence of PH in patients with MCTD.
研究了血清血管紧张素I转换酶（ACE）活性（一种可能的肺内皮损伤标志物）与混合性结缔组织病（MCTD）患者肺动脉高压（PH）发生之间的关系。在使用皮质类固醇治疗前，MCTD合并PH患者（n = 6）的平均血清ACE水平为26.4±14.0 mU/ml，MCTD但无PH患者（n = 18）为16.8±4.1 mU/ml，未分化结缔组织病患者（n = 14）为16.8±4.1 mU/ml，对照组（n = 18）为16.5±3.9 mU/ml。各组间酶活性无显著差异。然而，4例MCTD患者的ACE水平升高（> 28.3 mU/ml），且均患有PH。我们的结果表明，血清ACE活性升高可能与MCTD患者PH的发生有关。
