Hoffmann W, Schiller U, Rodemann H P, Bamberg M
Abteilung für Strahlentherapie, Eberhard-Karls-Universität, Tübingen.
Strahlenther Onkol. 1995 Feb;171(2):106-12.
Retinoids are a class of compounds structurally related to vitamin A which have been found to be active agents experimentally as well as clinically in the prevention and treatment of tumors. The data available suggest to study whether they might improve treatment results if combined with irradiation.
The clinical results in the prevention and treatment of cancer with retinoids are reviewed. In the context of experimental studies evaluating the antiproliferative effects of retinoids, cytokines and radiation alone or in combination our own experimental investigations analyzing a combination of all-trans-retinoic acid, interferon-alpha (IFN-alpha) and ionizing radiation in squamous cell carcinoma cell lines are described.
There is a solid body of experimental and clinical data to combine retinoids with cytokines (e.g.IFN-alpha). Since it is known that vitamin A alters the radiation response in experimental tumors our analyses further support the combination of retinoids and IFN-alpha with ionizing radiation.
We emphasize further clinical investigations evaluating the combined treatment with retinoids/IFN-alpha and ionizing radiation in squamous cell carcinomas such as head and neck tumors and cervical cancer.
类视黄醇是一类在结构上与维生素A相关的化合物，已发现在预防和治疗肿瘤方面，它们在实验和临床中均为活性剂。现有数据表明，研究它们与放射治疗联合使用是否能改善治疗效果。
回顾了类视黄醇在癌症预防和治疗方面的临床结果。在评估类视黄醇、细胞因子和放射单独或联合使用的抗增殖作用的实验研究背景下，描述了我们自己对全反式维甲酸、α干扰素（IFN-α）和电离辐射联合作用于鳞状细胞癌细胞系的实验研究。
有大量实验和临床数据支持将类视黄醇与细胞因子（如IFN-α）联合使用。由于已知维生素A会改变实验性肿瘤的放射反应，我们的分析进一步支持将类视黄醇和IFN-α与电离辐射联合使用。
我们强调进一步开展临床研究，评估类视黄醇/IFN-α与电离辐射联合治疗头颈部肿瘤和宫颈癌等鳞状细胞癌的效果。
