Dzhanashiia P Kh, Zhiliaev E V, Glazunov A V, Nesterenko V I
Ter Arkh. 1994;66(10):75-9.
20 mg of nifedipine, 160 mg of verapamil and 120 mg of diltiazem were given to 53 patients aged 60-90 (33 males and 20 females) with stable angina pectoris and painless myocardial ischemia. Bicycle exercise tests employed to evaluate antianginal activity of the above drugs showed them to significantly prolong the period of exercise free of a 1-mm depression of the ST segment. This was true both for males and females. In females nifedipine produced the weakest effect. Anti-ischemic activity of the drugs appeared to depend on the presence of arterial hypertension and voltage signs of left ventricular hypertrophy, initial exercise tolerance and heart rate, blood triglyceride concentrations, left ventricular end-diastolic volume, the size of the left atrium, interventricular septum thickness, etc. To prognosticate the effect of each of the 3 drugs as well as nifedipine paradoxical action in some patients the authors propose to use classification trees, providing a significant branching virtually in all relevant points.
给53名年龄在60至90岁之间（33名男性和20名女性）患有稳定型心绞痛和无痛性心肌缺血的患者分别服用20毫克硝苯地平、160毫克维拉帕米和120毫克地尔硫䓬。用于评估上述药物抗心绞痛活性的自行车运动试验表明，这些药物能显著延长无ST段压低1毫米的运动时间。男性和女性均如此。在女性中，硝苯地平的效果最弱。这些药物的抗缺血活性似乎取决于动脉高血压的存在、左心室肥厚的电压征象、初始运动耐量和心率、血液甘油三酯浓度、左心室舒张末期容积、左心房大小、室间隔厚度等。为了预测这三种药物中每种药物的效果以及某些患者中硝苯地平的反常作用，作者建议使用分类树，它几乎在所有相关点都能提供显著的分支。
