对阿法沙龙（alphaxalone）的免疫介导反应。
Immune-mediated reactions to althesin (alphaxalone).
作者信息
Watkins J, Clark A, Appleyard T N, Padfield A
出版信息
Br J Anaesth. 1976 Sep;48(9):881-6. doi: 10.1093/bja/48.9.881.
Measurements of complement conversion and white cell variations were made on sequential blood samples obtained from a single volunteer following repeated administration of Althesin. The results suggest a mechanism by which a clinically significant hypersensitivity reaction to the drug might be mediated. Studies of patients receiving routine anaesthesia revealed a very high incidence of subclinical "hypersensitivity" reaction, some of which appear to be immune-mediated. These reactions occurred irrespective of whether the patients were induced with Althesin, methohexitone or propanidid.
对一名志愿者反复注射阿法沙龙后采集的系列血样进行了补体转化和白细胞变化的测量。结果提示了一种可能介导对该药物产生具有临床意义的超敏反应的机制。对接受常规麻醉的患者的研究显示，亚临床“超敏”反应的发生率非常高，其中一些似乎是免疫介导的。无论患者是用阿法沙龙、甲己炔巴比妥还是丙泮尼地诱导麻醉，这些反应都会发生。
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