甘油三亚油酸酯抑制肾上腺素诱导的人血小板聚集。

Trilinolein inhibits epinephrine-induced human platelet aggregation.

作者信息

Lai L J, Shen Y C, Hong C Y

机构信息

Institute of Traditional Medicine, National Yang-Ming University Medical College, Taipei, Taiwan, ROC.

出版信息

Thromb Res. 1994 Nov 1;76(3):281-7. doi: 10.1016/0049-3848(94)90199-6.

DOI:10.1016/0049-3848(94)90199-6

PMID:7863478

Abstract

At concentrations ranging from 10(-9) to 10(-6) M, trilinolein inhibited epinephrine-induced platelet aggregation. This inhibition was accompanied by reduced ATP release and thromboxane B2 formation. However, concentration-response curves for the interaction between trilinolein and epinephrine showed that trilinolein was unlikely a competitive antagonist of epinephrine. Platelet aggregation induced by collagen, thrombin, ADP or arachidonic acid was not inhibited. This study supported the theory that this type of triglyceride may have therapeutic potential but the definite mechanism for its effect remains to be answered.

摘要

在浓度范围为10⁻⁹至10⁻⁶ M时，三油酸甘油酯抑制肾上腺素诱导的血小板聚集。这种抑制伴随着ATP释放减少和血栓素B2生成减少。然而，三油酸甘油酯与肾上腺素相互作用的浓度-反应曲线表明，三油酸甘油酯不太可能是肾上腺素的竞争性拮抗剂。由胶原、凝血酶、ADP或花生四烯酸诱导的血小板聚集未受到抑制。本研究支持了这种类型的甘油三酯可能具有治疗潜力的理论，但其作用的确切机制仍有待解答。