Olschewski H, Seeger W
Justus-Liebig-Univ. Giessen, Medizinische Klinik II.
Z Kardiol. 1994;83 Suppl 6:181-91.
Severe pulmonary hypertension has a poor prognosis and is complicated to treat. It is caused by states of hypoxia, thromboembolism, chronic inflammation, pulmonary venous congestion and/or hypercirculation. In the course of some days up to many years, remodelling of the pulmonary vasculature may occur. Morphologic characteristics of the remodelling process have extensively been described, while the underlying cellular and molecular mechanisms remain largely unknown. Increasing knowledge of the features of pulmonary vasoconstriction and vascular remodelling, will, however, improve the options for future therapy.
重度肺动脉高压预后较差且治疗复杂。它由缺氧、血栓栓塞、慢性炎症、肺静脉淤血和/或高循环状态引起。在数天至数年的病程中，可能会发生肺血管重塑。虽然已经广泛描述了重塑过程的形态学特征，但潜在的细胞和分子机制在很大程度上仍不清楚。然而，对肺血管收缩和血管重塑特征的了解不断增加，将改善未来的治疗选择。
