Suo J, Tanaka N, Hizuta A, Yunoki S, Orita K
First Department of Surgery, Okayama University Medical School, Japan.
Acta Med Okayama. 1994 Oct;48(5):237-42. doi: 10.18926/AMO/31113.
PSK (Krestin) is a protein-bound polysaccharide with antitumor and immunomodulatory activity. In this study, the effects of the oral administration of PSK were investigated on the natural killer (NK) activity of liver-associated lymphocytes and their subfractions separated by density gradient centrifugation, in WKAH rats with liver metastasis of KDA hepatoma. PSK was administered orally, at a dose of 500 mg/kg once a day for 3 weeks. The NK activity of nonparenchymal liver cells (NPLC) and their subfractions, including large granular lymphocytes (LGL), was markedly augmented by this treatment. The effects of oral PSK were also examined in CDF1 mice with liver metastases of Colon 26 adenocarcinoma; the survival of tumor-bearing mice was prolonged and both metastatic foci and liver weight were decreased. These results suggest that PSK may be effective for the suppression of liver metastasis through activation of liver-associated NK cells.
PSK（云芝多糖K）是一种具有抗肿瘤和免疫调节活性的蛋白结合多糖。在本研究中，对患有KDA肝癌肝转移的WKAH大鼠，研究了口服PSK对肝脏相关淋巴细胞及其通过密度梯度离心分离的亚组分的自然杀伤（NK）活性的影响。以500mg/kg的剂量每天口服一次PSK，持续3周。这种治疗显著增强了非实质肝细胞（NPLC）及其亚组分（包括大颗粒淋巴细胞（LGL））的NK活性。还在患有结肠26腺癌肝转移的CDF1小鼠中检查了口服PSK的效果；荷瘤小鼠的生存期延长，转移灶和肝脏重量均降低。这些结果表明，PSK可能通过激活肝脏相关NK细胞对抑制肝转移有效。
