Shu J, Li K Y, Huang D K
Department of Neurobiology, Shanghai Medical University, P. R. China.
Acupunct Electrother Res. 1994 Jun-Sep;19(2-3):107-17. doi: 10.3727/036012994816357330.
This study had the objective to understand the central effect of electro-acupuncture analgesia (EAA) on visceral pain of rats. We used the method of Sokoloff's 2-deoxyglucose (2-DG) auto-radiographic quantitative analysis to observe the changes of local cerebral metabolic rate of glucose (LCMRG) in rats given electrical stimulation of greater splanchnic nerve (GSN) followed by electro-acupuncture. From the results of this study, we found that the LCMRG had a significant difference between EAA group and pain group at some structures, such as the spinal thoracic and lumbar dorsal horns (segments T6-T8, L1-L3), locus coeruleus (lc), nucleus raphe magnus (rm), nucleus reticular gigantocellularis (rgi), periaqueductal gray (PAG) and habenulae lateralis (hl) of thalanum. The results combining reports by other investigators, suggest that these local cerebral structures might be the key nuclei in EAA on visceral pain.
本研究旨在了解电针镇痛（EAA）对大鼠内脏痛的中枢效应。我们采用索科洛夫2-脱氧葡萄糖（2-DG）自动放射自显影定量分析方法，观察电刺激大鼠内脏大神经（GSN）后进行电针时，大鼠局部脑葡萄糖代谢率（LCMRG）的变化。从本研究结果中，我们发现EAA组和疼痛组在某些结构上LCMRG存在显著差异，如脊髓胸段和腰段背角（T6-T8节段、L1-L3节段）、蓝斑（lc）、中缝大核（rm）、巨细胞网状核（rgi）、导水管周围灰质（PAG）和丘脑外侧缰核（hl）。结合其他研究者的报告结果表明，这些局部脑结构可能是EAA治疗内脏痛的关键核团。
