Le Bouedec G, Kauffmann P, Pingeon J M, Pomel C, Dauplat J
Centre Jean-Perrin, Clermont-Ferrand.
Ann Chir. 1994;48(7):607-12.
Between 1978 and 1991, one hundred and thirty-six surgical excision biopsies were performed in our institution for clinically occult breast cancers. A retrospective analysis of histopathologic characteristics was carried out in order to determine the prognostic factors of these cancers detected by mammography. Mammographic findings consisted of microcalcifications alone (49 cases), microcalcifications with opacity (20 cases), stellate opacity (52 cases) and well-circumscribed opacity (12 cases). Preoperative localization was achieved by mammography in 109 cases and ultrasonography in 27 cases. The size of malignant lesions ranged from 3 to 25 mm, 76 lesions were less than 10 mm in diameter. The histopathologic findings were as follows: invasive ductal cancer (IDC) 113 cases (83%), invasive lobular cancer (ILC) 11 cases (8%), ductal or lobular cancer in situ with microinvasion 12 cases (9%). Breast conserving treatment was performed in 106 cases (78%). A high proportion of well differentiated tumors was encountered-59 grade I (52%) were identified out of 113 IDC-and the incidence of axillary node metastases was less than 10%. Clinically occult breast cancers seem to exhibit favorable prognostic factors.
1978年至1991年间，我院对临床隐匿性乳腺癌进行了136例手术切除活检。为了确定这些通过乳房X线摄影检测出的癌症的预后因素，对其组织病理学特征进行了回顾性分析。乳房X线摄影表现包括单纯微钙化（49例）、微钙化伴致密影（20例）、星芒状致密影（52例）和边界清晰的致密影（12例）。109例术前通过乳房X线摄影定位，27例通过超声定位。恶性病变大小为3至25毫米，76个病变直径小于10毫米。组织病理学结果如下：浸润性导管癌（IDC）113例（83%），浸润性小叶癌（ILC）11例（8%），导管或小叶原位癌伴微浸润12例（9%）。106例（78%）进行了保乳治疗。发现高比例的高分化肿瘤——113例IDC中有59例（52%）为I级——腋窝淋巴结转移发生率低于10%。临床隐匿性乳腺癌似乎表现出良好的预后因素。
