X射线照射的大肠杆菌中的羟基自由基与DNA双链断裂
Hydroxyl radicals and DNA double-strand breaks in X-irradiated E. coli.
作者信息
Ewing D, Damsker K E
机构信息
Department of Radiation Oncology & Nuclear Medicine, Hahnemann University, Philadelphia, Pennsylvania 19102.
出版信息
Biochem Biophys Res Commun. 1995 Feb 27;207(3):957-62. doi: 10.1006/bbrc.1995.1278.
PMID:7864901
Abstract
We have used glycerol to study the relationship between hydroxyl radicals, one of the primary radiolytic products, and the production of DNA double-strand breaks in selected E. coli strains. Our results suggest that when bacteria are irradiated at doses up to about 120 Gray, hydroxyl radicals produce DNA lesions, but not double-strand breaks.
摘要
我们使用甘油来研究主要辐射分解产物之一的羟基自由基与特定大肠杆菌菌株中DNA双链断裂产生之间的关系。我们的结果表明，当细菌受到高达约120戈瑞的剂量照射时，羟基自由基会产生DNA损伤，但不会产生双链断裂。
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