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利用甘油将羟基自由基造成的DNA损伤与DNA修复酶的活性联系起来。

The use of glycerol to link DNA damage from hydroxyl radicals with the activities of DNA repair enzymes.

作者信息

Ewing D, Damsker K E

机构信息

Department of Radiation Oncology and Nuclear Medicine, Hahnemann University, Philadelphia, Pennsylvania 19102.

出版信息

Biochem Biophys Res Commun. 1995 Feb 15;207(2):515-20. doi: 10.1006/bbrc.1995.1218.

DOI:10.1006/bbrc.1995.1218
PMID:7864837
Abstract

We show that glycerol can be used to study the relationship between DNA damage caused by hydroxyl radicals and the activities of different DNA repair enzymes. We suggest that such tests with glycerol will lead to a better understanding of the mechanistic basis for radiation-induced cell death, as well as provide valuable information on the specific roles of different DNA repair enzymes.

摘要

我们表明，甘油可用于研究羟基自由基引起的DNA损伤与不同DNA修复酶活性之间的关系。我们认为，用甘油进行此类测试将有助于更好地理解辐射诱导细胞死亡的机制基础，并提供有关不同DNA修复酶具体作用的有价值信息。

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