Criado J R, Thies R
Department of Neuropharmacology, Scripps Research Institute, La Jolla, CA 92037.
Alcohol. 1994 Nov-Dec;11(6):533-8. doi: 10.1016/0741-8329(94)90080-9.
This study examined the dose-dependent effects of acute ethanol on recurrent inhibitory mechanisms of hippocampal CA1 neurons in anesthetized rats. The effects of micropressure-ejected GABAergic compounds were studied on evoked field responses and recurrent inhibition of CA1 pyramidal neurons. None of the systemic doses of ethanol examined altered recurrent inhibition of CA1 neurons. In contrast, local application of both GABAa and GABAb compounds produced clear changes in evoked field responses and blocked recurrent inhibition. These results suggest that (a) recurrent inhibition in the CA1 region in vivo is resistant to the effects of ethanol, and (b) both GABAergic receptor subtypes modulate recurrent inhibition in the CA1 region in vivo.
本研究检测了急性乙醇对麻醉大鼠海马CA1神经元反复抑制机制的剂量依赖性效应。研究了微压喷射的GABA能化合物对诱发场反应和CA1锥体神经元反复抑制的影响。所检测的乙醇全身剂量均未改变CA1神经元的反复抑制。相反，局部应用GABAa和GABAb化合物均使诱发场反应产生明显变化并阻断反复抑制。这些结果表明：(a)体内CA1区的反复抑制对乙醇的作用具有抗性；(b)两种GABA能受体亚型均在体内调节CA1区的反复抑制。
